【SAMP8小鼠快速老化SAMp8小鼠實驗動物模型價格低】

快速老化SAMP8小鼠快速老化SAMp8小鼠部分用戶：寧夏醫(yī)科大學(xué)、中國中醫(yī)科學(xué)院、同濟醫(yī)院、中科院遺傳與發(fā)育研究所、北京師范大學(xué)、國家體育總局體育科學(xué)研究所、河北醫(yī)科大學(xué)，中國醫(yī)科大學(xué)、山東大學(xué)、齊魯醫(yī)院、復(fù)旦大學(xué)、瑞金醫(yī)院、中科院上海藥物研究所、上海交通大學(xué)、第二軍醫(yī)大學(xué)、第四軍醫(yī)大學(xué)、中科院生物物理所、南方醫(yī)科大學(xué)、武漢協(xié)和、中國醫(yī)學(xué)科學(xué)院等均使用本單位提供動物進行研究

有各月齡SPF級SAMP8小鼠快速老化SAMp8小鼠銷售價格優(yōu)惠，SPF級SAMR1小鼠SAMP8mice早老快速老化小鼠銷售價格優(yōu)惠，SAMP8小鼠快速老化SAMp8小鼠保質(zhì)保量，提供質(zhì)量合格證，SAMP8小鼠快速老化SAMp8小鼠可送貨到實驗室

STRAIN NAME: Senescence accelerated mouse/prone8
TYPE: Spontaneous mutation
BACKGROUND STRAIN: AKR/J
COAT COLOR: White (Albino)
ORIGIN: In 1968, the United States (Bar Harber ME) Jackson laboratory presented to a few of the AKR / J mice the in Kyoto, Japan (Kyoto) University,.in Feeding and breeding process, Takeda found several mice showed different degrees epilation, rough skin, cataracts, behavioral disorders and shortened survival phenomena and have a genetic predisposition. In 1975, they carefully selected the five nest obvious aging AKR / J mice as the P series ancestors, normal aging process of mice as the R line ancestor. Select the P series, R series main criteria for degree of aging (in 8 mon degree of aging), survival period and pathological changes based on diseases associated with aging. According to the survival curve (Gompertzian function) and degree of aging get P series mice as rapid aging [1]. Therefore, P series called senescence accelerated mouse (Senescence accelerated mouse / prone, SAMP), R series known as the anti-senescence accelerated mouse.
Biology: SAMP 8 brain have a large number of Aβ deposition in the aging process. Northern hybridization analysis showed that, β-amyloid precursor protein (APP) mRNA expression did not change significantly. SAMP 8 occurred learning, memory dysfunction and Neurotransmitter change in the brain during the aging, such as the cerebral cortex and hippocampus of acetylcholine (Ach), norepinephrine (NE), dopamine (DA) and opioid peptides reduce, γ-aminobutyric acid (GABA) increased, 5 - hydroxytryptamine (5-HT) showed first increased and then decreased and so on. SAMP 8 at 2 mon occurs immune dysfunction ,the sheep red blood cells (SRBC)-induced spleen cell antibody response, Con A-induced lymphocyte proliferation and IL-2 production capacity decreased significantly. Further study found that SAMP8 CD+4 cells decreased and function decline in the spleen, NK cells normal. NK cell activity was significantly enhanced After using immunostimulants, NK cell activity decreased possible relate with IL-2 levels decline.
RESEARCH APPLICATION: learning and memory dysfunction, Evaluation of anti-aging and improve learning and memory drugs